eso disease dps build
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ESO Disease DPS Build

A Disease damage based DPS Build for Solo and Group PVE in ESO! The Build is focusing on the Disease status effect and is using Disease damage based Skills and Armor Sets to clear content. The Best Class for the Build is the Stamina Necromancer, thanks to its various disease skills and effects! If you are a new player, you can take a look at my Necromancer Beginner Guide. You can find more Builds in the Necromancer Builds page. For more Elemental and Status Effects Builds you can take a look at ESO Elemental Builds!

Table of Contents

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ESO Disease DPS Build Setup

The Build is focusing on Disease damage based effects, Sets and skills to deal the best damage possible in Solo and Group gameplay!

HeadVelidrethMedium/LightDivinesMax. Stamina
ShouldersVelidrethMediumDivinesMax. Stamina
HandsAzureblight ReaperMediumDivinesMax. Stamina
LegsAzureblight ReaperMediumDivinesMax. Stamina
ChestAzureblight ReaperMediumDivinesMax. Stamina
WaistAzureblight ReaperMediumDivinesMax. Stamina
FeetAzureblight ReaperMediumDivinesMax. Stamina
NecklacePhylactery’s GraspJewelBloodthirstyWeapon Damage
RingPhylactery’s GraspJewelBloodthirstyWeapon Damage
RingPhylactery’s GraspJewelBloodthirstyWeapon Damage
One Hand WeaponPhylactery’s GraspDaggerPrecise/ChargedFire
One Hand WeaponPhylactery’s GraspDaggerChargedDisease
Two Handed Weapon(Perfected)Merciless Charge/Phylactery’s GraspGreatswordInfusedWeapon Damage

Armor Sets for ESO Disease DPS Build

Skills for ESO Disease DPS Build

The following Skills will help you achieve great DPS for Group and Solo content.

Deadly CloakVenom SkullSkeletal ArcherBlighted BlastbonesDetonating SiphonFlawless Dawnbreaker
StampedeCarveBarbed TrapSpirit GuardianRazor CaltropsPestilent Colossus
  • Deadly Cloak(Blade Cloak): Strong DPS skill.
  • Venom Skull(Flame Skull): Strong spammable.
  • Skeletal Archer(Skeletal Mage): Summon an undead minion to assist in combat that also creates a corpse on death.
  • Blighted Blastbones(Blastbones): Great source of disease damage for Necromancer.
  • Detonating Siphon(Shocking Siphon): Use this skill to increase Your damage passively but also to deal additional disease damage by exploiting corpses.
  • Flawless Dawnbreaker(Dawnbreaker): Placed here to boost Weapon Damage. No need to use it.
  • Stampede(Critical Charge): Powerful AOE damage skill.
  • Carve(Cleave): Great Bleed damage skill that applies a shield.
  • Barbed Trap(Trap Beast): Very good DOT damage and a boost to Critical Damage.
  • Spirit Guardian(Spirit Mender): Minion that heals and reduces incoming damage.
  • Razor Caltrops(Caltrops): Debuffs enemies and deals damage.
  • Pestilent Colossus(Frozen Colossus): Main Ultimate. Deals great disease damage and applies Major Vulnerability.

Bow Back-Bar

If you wish to play with Bow as your Back-Bar Weapon, just replace Stampede and Carve with Endless Hail(Volley) and Poison Injection(Poison Arrow).

Passive Skills for ESO Disease DPS Build

Very important passive skills that can help you maximize the potential of your Disease DPS Build.

  • All Passive Skills from your Class’ Lines
  • All Passive Skills from Weapon Lines you are using
  • Passive Skills from Armor Lines you are using
  • Passive Abilities from Guild lines(Fighters Guild, Mages Guild, Psijic Order) that affect your skills/Build
  • Fighters Guild Passives: Intimidating Presence, Slayer, Banish the Wicked, Skilled Tracker
  • Mages Guild Passives: Mage Adept, Everlasting Magic, Magicka Controller, Might of the Guild
  • Undaunted Passives
  • Your Racial Passives
  • Medicinal Use Passive from Alchemy to boost the effectiveness of Potions

Champion Points for ESO Disease DPS Build

Below you will find the best Champion Points setup for the Build. If you would like to learn more about Champion Points and how they work, you can read my ESO Champion Points Guide.


  • Slottable Stars: Deadly Aim, Master-at-Arms, Wrathful Strikes, Fighting Finesse
  • Passive: Tireless Discipline, Piercing, Battle Mastery, Mighty, Quick Recovery, Hardy, Elemental Aegis, Preparation, Precision, Blessed, Eldritch Insight


  • Slottable Stars: Rationer, Liquid Efficiency, Master Gatherer, Steed’s Blessing
  • Passive: Gilded Fingers, Fortune’s Favor, Wanderer, Steadfast Enchantment, Treasure Hunter(slottable, required for path)


  • Slottable Stars: Bloody Renewal/Celerity, Fortified, Rejuvenation, Boundless Vitality
  • Passive: Sprinter, Hasty, Tireless Guardian, Hero’s Vigor, Mystic Tenacity, Tumbling, Defiance

Consumables for ESO Disease DPS Build

We are using Artaeum Takeaway Broth as Food and Essence of Weapon Power as Potions.

Info for ESO Disease DPS Build

Several important info for the Disease DPS Build. What Mundus to use, the best race for the build and how to assign your attribute points.

Attribute Points

All points to Stamina

Mundus Stone

The Thief Mundus to boost Critical Chance.

What Race is best for Disease DPS Build

Dark Elf – Orc – Khajiit is the best race for a DPS focused Build. Any Race with Stamina bonuses can work well though. You can find more about the playable races in my ESO Race Guide!

Vampire or Werewolf

Neither is necessary.

Rotation for ESO Disease DPS Build

Drink a Potion, summon your Skeletal Archer, Spirit Guardian(when necessary), set your Barbed Trap and attack with Stampede, Carve x3, Razor Caltrops(when solo). Switch bars and continue with Blighted Blastbones, Skeletal Archer, Deadly Cloak, Blighted Blastbones, Detonating Siphon, Venom Skull, Blighted Blastbones, Venom Skull x2, Blighted Blastbones, switch bars. Use Blighted Blastbones always after every two skills and re cast the other abilities when necessary. Use Pestilent Colossus when ready and always Light Attack before every skill/action to boost damage!